1) Cancer is a serious disease, but when a tumor is localized, it can be removed by surgery. Skin cancer, the most common form of the disease, can usually be treated this way. Melanomas, the most serious form of skin cancer, can be removed surgically, but only if spotted very early. 2) Other forms of treatment make use of the fact that cancer cells grow rapidly and, therefore, need to copy their DNA more quickly than do most normal cells. This makes them especially vulnerable to damage from radiation. As a result, many tumors can be effectively treated with carefully targeted beams of radiation. 3) Medical researchers have worked for years to develop chemical compounds that would kill cancer cells, or at least slow their growth. The use of such compounds against cancer is known as chemotherapy. Great advances in chemotherapy have taken place in recent years and have even made it possible to cure some forms of cancer. However, because most chemotherapy compounds target rapidly dividing cells, they also interfere with cell division in normal, healthy cells. This produces serious side effects in many patients, and it is one of the reasons why scientists are so interested in gaining a better understanding of cell cycle proteins in cancer. The goal of many researchers is to find highly specific ways in which cancer cells can be targeted for destruction while leaving healthy cells unaffected. 4) Understanding and combating cancer remains a major scientific challenge, but scientists at least know where to start. Cancer is a disease of the cell cycle, and conquering cancer will require a much deeper understanding of the processes that control cell division.
Which word or words can we use to replace the word "therefore" in paragraph (2)?